Ayesha is one of the 47 woredas in the Somali Region of Ethiopia. Part of the Shinile Zone, Ayesha is bordered on the south by Dembel, on the southwest by Shinile, on the west by Erer, on the north by Djibouti, on the east by Somalia, and on the southeast by the Jijiga Zone. Towns and cities in Ayesha include Ayesha, Dewele, Laserat and Mermedebis.

Ayesha, the Return of She is a gothic novel by the popular Victorian author H. Rider Haggard, published in 1905, as a sequel to his far more popular and well known novel, She.

The girl's name Ayesha is of Persian origin, and its meaning is "small one". 'Ayesha' also means 'beautiful'. In Arabic, Ayesha means 'life' and can also be spelled 'Aisha'.