Big Business is a 1929 silent Laurel and Hardy comedy short subject directed by James W. Horne and supervised by Leo Mc Carey from a McCarey (uncredited) and H. M. Walker script.

Big Business is a 1988 farcical comedy film starring Lily Tomlin and Bette Midler. Its premise was two pairs of identical twins who were mixed up as babies. One Midler-Tomlin pair ends up in a rich urban family, while the other pair ends up in a poor rural family, and coincidentally the rich twins seek to strip mine the small town, called Jupiter Hollow, in which the poor twins live.

Big Business is a stoner rock/sludge metal band currently signed to Hydra Head Records. Originally from the Seattle area, the band relocated to Los Angeles in February, 2006.

Big Business is a double mixtape album by southern rappers Chamillionaire and Stat Quo. The first CD is a regular and the second is a chopped and screwed version by OG Ron C. It has sold almost 150 thousand copies to date according to soundscan.