Comacchio is a town of Emilia Romagna, Italy, in the province of Ferrara, 48 km by road from the town of Ferrara, in the centre of the lagoon of Valli di Comacchio, just north of the present mouth of the Reno. It is built on more than thirteen different islets, joined by bridges. Industries and include fishery, which belongs to the commune, and salt-works.