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condition of facial difference (craniosynostosis) characterized by underdevelopment of the bones in the middle third of the face and skull; a high, flat, prominent forehead and increased head width, bulging of the eyes, strabismus, receded upper jaw, high and narrow palate.

is a genetic condition with features of craniosynostosis (the early closure of skull sutures) and abnormal development of the eye sockets and midface. There is abnormal fusion between some of the bones of the skull and face that does not allow the bones to grow normally. The features of Crouzon syndrome were first described by the French neurosurgeon Dr. O. Crouzon in 1912. Crouzon syndrome is caused by mutations in Fibroblast Growth Factor Receptor 2.

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