A protein which specifically binds to estrogen and mediates its biological activity. When present in breast and other cancers, predicts response to hormonal therapy.
A message-carrying protein that takes estrogen and brings it into the cell. Once inside the cell nucleus, estrogen can give the signal for a tumor cell to grow.
a protein that is assembled in a breast cell after binding to an estrogen
a protein that's found in many cells of the body
Protein inside certain cells that binds to estrogen.
A substance in the body that binds to estrogen. The receptor is like a lock mechanism, and estrogen is the key that fits the lock. Estrogen only works in the body if it binds to an estrogen receptor.
a protein molecule dissolved in the aqueous nuclear medium that is coded for estrogen.
ER. Protein found on some breast cancer cells to which estrogen will attach. Breast cancer cells that are estrogen receptor positive (ER+) need the hormone estrogen to grow and usually respond to hormone treatment.
A cellular protein that binds hormones, found on nearly all cell types, but particularly in estrogen-sensitive tissues like those in the uterus and the breast. The weak estrogenic qualities of soy isoflavones may function as Antiestrogens because they can compete with endogenous estrogen for binding to estrogen receptors. In doing so, they block the more potent endogenous estrogens from exerting their effect. Since high blood levels of estrogen are an established risk factor for breast cancer, weak estrogens have been postulated as being protective against this form of cancer.
An estrogen receptor (ER) is a nuclear receptor for estrogens such as estradiol (the main endogenous human estrogen). Estrogen receptors are intracellular proteins like other steroid hormone receptors. Some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogenDragoslava Zivadinovic and Cheryl S.