in genetic engineering, the cells (host organism) into which a gene is inserted to manufacture desired proteins; the gene is combined with a genetic vector (such as a virus or circular DNA molecule called a plasmid) to provide the genetic context in which it will function in the cell; that is, the gene will be expressed as the protein of interest.
A cell culture system into which a foreign DNA can be introduced as part of a specialized vector that enables it to be expressed as protein.
A cell-based protein synthesis system programmed by an expression vector.
In HIV vaccine production, cells into which an HIV gene has been inserted to produce desired HIV proteins. Back to the Top
In genetic engineering, the cells into which a gene has been inserted, with the aim of producing its encoded protein. Chinese hamster ovary (CHO) cells and baculovirus/insect cells are two expression systems often used to make recombinant HIV vaccines.
a powerful tool for investigating the function of endogenous proteins
Organisms chosen to manufacture (by expression) a protein of interest through recombinant DNA technology.
A system in which a cloned gene can be expressed. Elements used to evaluate the quality of an expression system include the number of copies of the gene per cell, the strength of the transcriptional promoter, the presence of the bacterial ribosome binding site, codon usage, and the fate of the protein.
in genetic engineering, the cells into which a gene has been inserted to manufacture desired proteins. Chinese hamster ovary (CHO) cells and baculovirus/insect cells are two expression systems that are used to make recombinant HIV vaccines. functional antibody: an antibody that binds to an antigen and has an effect that can be demonstrated in laboratory tests. For example, neutralizing antibodies are functional antibodies that inactivate HIV or prevent it from infecting other cells. gag: a gene of HIV that codes for p55, the core protein. p55 is the precursor of HIV proteins p17, p24, p7 and p6 that form HIV's capsid or core, the inner protein shell surrounding HIV's strands of RNA.