A histomorphometric method that was developed by Donald Gleason to classify adenocarcinoma of the prostate by evaluating the pattern of glandular differentiation. The tumour grade is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.
two Gleason Grade numbers are added together to produce the Gleason Score. The first Gleason Grade number indicates the Gleason Grade of the cancer cells found most commonly within the sample, the second number the second most commonly found grade. For example, a Gleason Score of 4+3=7 means that Gleason Grade 4 is the most commonly found type of cell, Gleason Grade 3 the second most commonly found, producing a total Gleason Score of 7. Related Paper
A system of grading prostate cancer. The Gleason grading system assigns a grade to each of the two largest areas of cancer in the tissue samples. Grades range from 1 to 5), with 1 being the least aggressive and 5 the most aggressive. Grade 3 tumors, for example, seldom have metastases, but metastases are common with grade 4 or grade 5. The two grades are then added together to produce a Gleason score. A score of 2 to 4 is considered low grade; 5 through 7, intermediate grade; and 8 through 10, high grade. A tumor with a low Gleason score typically grows slowly enough that it may not pose a significant threat to the patient in his lifetime.
A standard system of grading prostate tumor tissue seen under the microscope. The pathologist reports it as a number between 2 and 10. The lower the number, the lower the statistical risk. The higher the number, the higher the statistical risk.
a way to describe differences in prostate cancer cells
A number from 2 to 10, obtained by adding the Gleason grades from the two most abnormal areas in the prostate tissue being examined.
A system of grading prostate cancer cells describing how aggressive the cancer appears. It is used to determine the best treatment and to predict how well a person is likely to respond to treatment. The lower the Gleason score, the closer the cancer cells are to normal cells, the higher the Gleason score, the more abnormal the cancer cells.
a classification of adenocarcinoma (glandular cancer) of the prostate by evaluation of the pattern of glandular differentiation. The score is the sum of the dominant and secondary patterns, each numbered on a scale of 2 (best) to 10 (worst).
a rating system that identifies the aggressiveness of a cancer. A Gleason score of less than 6 is considered less aggressive, and a score greater than 7 is considered more aggressive.
A cancer is usually made up of cells at several different stages of development and differentiation. Dr. Gleason set up a classification of five different grades that can help determine the type of cancer. He looked at the two most prevalent types of cells and gave each type a grade of 1 to 5 then added the two scores for a final grade. A tumor with well differentiated cells would have a score of 2, 3, or 4 and be classified as low grade. A tumor with moderately differentiated cells would be scored as a 5, 6 or 7 and would be a middle or moderate grade. A tumor with poorly differentiated cells would be score as an 8,9 or 10 and would be a high grade tumor. The high grade tumors are usually very aggressive and life threatening.
(GLEE-sun...) A system of grading prostate cancer tissue based on how it looks under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer tissue is similar to normal prostate tissue and the tumor is less likely to spread; a high Gleason score means the cancer tissue is very different from normal and the tumor is more likely to spread.
(GLEE-sun) A system of grading prostate cancer cells based on how they look under a microscope. Gleason scores range from 2 to 10 and indicate how likely it is that a tumor will spread. A low Gleason score means the cancer cells are similar to normal prostate cells and are less likely to spread; a high Gleason score means the cancer cells are very different from normal and are more likely to spread.
A score (2-10) that helps doctors determine how aggressive prostate cancer is.
A system of grading prostate cancer cells based on how they look under the microscope - a high Gleason score means the tumor is more likely to grow and spread than a tumor with a low Gleason score
A widely used grading system for determining the aggressiveness of cancer cells.
A system of grading prostate cancer cells to determine the best treatment and to predict how well a person is likely to do. A low Gleason score means the cancer cells are very similar to normal prostate cells; a high Gleason score means the cancer cells
A widely used method for classifying the cellular differentiation of cancerous tissue. The less the cancerous cells appear like normal cells, the more malignant the cancer. Two grades of 1-5, identifying the two most common degrees of differentiation present in the examined tissue sample, are added together to produce the Gleason score. High numbers indicate greater differentiation and more aggressive cancer. The grading system is name after its originator, Donald Gleason, M.D.
a system for grading prostate cancer tumours according to size and severity.
A way of grading cancer cells. Low grade cancers (Gleason score 2,3,4) are slower growing than high grade (Gleason scores 8,9,10) cancers. (See Mr PHIP No. 3)
a rating system that indicates how aggressive a cancer is. The higher the Gleason score, the more likely it is that the cancer will grow and spread rapidly. Pathologists often identify the two most common patterns of cells in the tissue, assign a Gleason grade to each, and add the two grades. The result is a number between two and 10. A Gleason score of less than six indicates a less aggressive cancer. A grade seven and up is considered more aggressive.
A method of classifying prostate cancer cells on a scale of 2 to 10. The higher the Gleason score (also called the Gleason sum), the faster the cancer is likely to grow.
Used in the Gleason grade system which is the most common system used in the United States to grade the appearance of prostate cancer tissue.
A system for rating the microscopic patterns and potency of a cancer.
When prostate cancer is detected, a biopsy will take small samples of tissue from the prostate. A pathologist will evaluate the tissue and assign a Gleason Grade/Score to two separate areas in the samples - ranging from 1 to 5, each. The higher the number (2 -10), the more aggressive is the cancer.
A way of describing how aggressive a patient's prostate cancer is. The Gleason score may be between Gl 2 and Gl 10. See prostate cancer section.
a method of classifying prostate cancer cells on a scale of 2 to 10. The higher the Gleason score the faster the cancer is likely to grow and the more likely it is to spread beyond the prostate. See also, Gleason grade.
A Gleason score is given to prostate cancer based upon its microscopic appearance. The Gleason score is important because higher Gleason scores are associated with worse prognosis. This is because higher Gleason scores are given to cancer which is more aggressive.