The technique of using automated assays to search through large numbers of compounds for desired activity.
Rapid evaluation of large numbers of chemical compounds to determine which one(s) interact with a given drug target, usually a protein.
The method by which very large numbers of compounds are screened against a putative drug target in either cell-free or whole-cell assays. Typically, these screenings are carried out in 96 well plates using automated, robotic station based technologies or in higher- density array ("chip") formats.
Process for rapid assessment of the activity of samples from a combinatorial library or other compound collection, often by running parallel assays in plates of 96 or more wells. A screening rate of 100 000 assays per day has been termed "Ultra High-Throughput Screening" (UHTS).
the use of automated processes to rapidly screen potential therapeutic agents e.g. antibodies.
A method of screening a large number of compounds against drug targets. These screenings are usually performed in 96-well plates using automated technologies. Histones Type of protein rich in lysine and arginine found in association with DNA in chromosomes.
(also: ultra-high-throughput screening) Automated in vitro testing of substances for their effects in biological systems (cells, modified cells, enzymes). The tests are performed with the aid of computer- or robot-controlled processes. More than 200,000 substances can be tested per day in this way.
process by which robotics are used to test the reactions of thousands of assays of different compounds against a target.3 K L UVWXYZ
A technique to analyze a large number of compounds in biological assays in parallel in order to identify molecules with specific biological effects from large compound libraries.
Automated robotic systems which allow scientists to automatically search and screen gene sequences.
The testing of potential compounds from a combinatorial library or other compound collection for biological activity in an accelerated mode (in groups of hundreds or thousands rather than 10 or 20) made possible through the use of automation and robotics.
The use of miniaturized, robotics-based technology to screen large compound libraries against an isolated target protein, cell or tissue in order to identify binders that may be potential new drugs. In conjunction with genomics (the identification of large numbers of potential therapeutic targets), and combinatorial chemistry (the production of large numbers of medicinally relevant compounds), high-throughput screening has revolutionized the capacity of pharmaceutical and biotechnology companies to identify potential new drugs. High-throughput screening depends on the development of a quantitative, pharmacologically relevant assay for the identified target, which can then be reproduced across a large number of samples. Typically, high-throughput screening has relied on 96-well plates as the standard, although higher-density formats (356, 712) are possible. Recently, advances in miniaturization and microfluidics have allowed screening of up to 100,000 compounds against a target on a single chip daily, allowing previously unimaginable amounts of compounds to be screened. Source : Celera Genomics
High-throughput screening (HTS), is a method for scientific experimentation especially used in drug discovery and relevant to the fields of biology and chemistry.