Saint Irene (Greek: Ειρήνη, Eirēnē) (c. 752 – August 9, 803) was Byzantine empress from 797 to 802. As monarch she called herself basileus (βασιλεύς), "emperor", rather than basilissa (βασίλισσα), "empress".

Irene is a musical with a book by James Montgomery, lyrics by Joseph McCarthy, and music by Harry Tierney.