genes that are associated with the formation of cancerous tissues (carcinogenesis).
A gene whose protein product causes uncontrolled cell growth (cancer). Normal cells divide under a very specific program called the cell cycle that is controlled by many genes. Oncogenes are sometimes produced as a result of a mutation in one or more of these genes. The mutation results in a malfunctional protein, which cannot perform its normal task to regulate cell growth or actually induces uncontrolled cell growth. Oncogenes are also found in viruses that introduce them into the host cells they infect to induce cancer; these are often mutant versions of proteins present in host cells.
Cancer gene present in the body. These can be activated by carcinogens and cause cells to grow uncontrollably.
typically designated by a 3-letter abbreviation, these are "genes which are essential to normal functioning of cells and organisms, but when genetically modified, or when the cellular mechanism controlling their expression is genetically altered, may cause affected cells to undergo a process called transformation, and become neoplastic (cancerous) cells."
A gene that, when changed by an injury or mutation, can result in the cell becoming a cancer cell. An inherited oncogene abnormality may cause cancers to run in families. (see Chromosome).
Any of several genes that control cell growth, division, and normal cell death, which can become mutated and cause cells to grow out of control, leading to cancer. These genes can be used to maintain stem cells as a self-renewing cell line in culture.
A gene that makes a normal cell grow abnormally and causes cancer.
Literally, a cancer causing gene. A gene, often with a normal function in controlling growth or differentiation, which when functioning abnormally (activated, for example, by amplification or mutation) confers on normal cells immortality or the ability to form tumours (transformation). Oncogenes that are commonly overexpressed or amplified in breast cancer include EGF-R, erbB-2, c-myc, c-myb and int-2/cyclin D1.
Any gene associated with cancer. Oncogenes are derived by the mutation of proto-oncogenes, normal cellular genes involved in growth control.
A gene that can cause normal cells to be transformed into cancer cells by promoting cell growth.
A gene found in all cells that may help convert normal cells to cancer cells
A gene that when expressed as a protein can lead cells to become cancerous, usually by removing the normal constraints on growth.
A gene which codes for a product which causes transformation of a normal cell into a cancer cell. Oncogenes are slightly changed equivalents of normal cellular genes called proto-oncogenes. The viral version is designated by the prefix v, the cellular version by the prefix c.
a decontrolled (mutated) proto-oncogene that leads to permanently active growth stimulation.
One of a large number of genes that can help make a cell cancerous. Typically, a mutant form of a normal gene (proto-oncogene) involved in the control of cell growth or division.
A type of gene that is normally inactive. When these genes are "turned on" (activated), they cause normal cells to change into cancer cells.
fragments of genetic material (DNA) that carry the potential to cause cancer (transform normal cells into malignant cells).
A mutation of a naturally occurring gene involved in growth regulation that results in uncontrolled growth. Oncogenes are associated with the development of some forms of cancer.
This is a mutated form of a proto-oncogene. In this form the gene can cause the cell to divide uncontrollably. This change, by itself or with other mutations, can cause a cell to become cancerous.
A type of gene. When these genes are abnormally “turned on” (activated), they cause excessive growth and other characteristics of malignancy. Oncologist: A physician who is specially trained in the diagnosis and treatment of cancer. Medical oncologists specialize in the use of chemotherapy and other drugs to treat cancer. Radiation oncologists specialize in the use of x-rays and other radiation to kill tumors. Surgical oncologists specialize in performing operations to remove cancer.
a gene that causes normal cells to change into cancerous tumor cells
a gene that can cause a cell to develop into a tumor cell, possibly resulting in cancer
a gene that causes or promotes cancerous changes within the cell
a gene that causes or promotes unrestrained growth of a cell
a gene that has sustained some genetic damage and, therefore, produces a protein capable of cellular transformation
a gene that is associated with a
a gene that produces cancer
a gene that will trigger cell growth abnormally, so if you block this you can inhibit cancer cell growth
a genetic sequence whose expression transforms a normal cell into a cancerous cell
a gene, viral derived or not, associated with cancer
an abnormal gene that may promote cancerous changes
a normal cell metabolism cellular gene which, when inappropriately cell metabolism expressed or mutated, can transform eukaryotic cells cell metabolism into tumour cells
a normal cellular gene which metabolism remedy, when inappropriately expressed or mutated metabolism remedy, can transform eukaryotic cells into tumour cells
a retrovirus-transduced and altered copy of a cellular gene for a thyroid hormone receptor
A mutated gene that is the cause of a cancer.
a gene which when altered can promote or allow uncontrolled cell growth, and thus cancer
A mutated proto-oncogene that is locked into an active state and continuously stimulates unregulated cell growth and proliferation that leads to tumor development. Myc, ras and erb are examples of oncogenes. The normal allele of an oncogene is called a proto-oncogene.
Genes which render cells malignant.
A gene whose product can cause cancer by stimulating abnormal cell growth and excessive proliferation. A mutant form of proto-oncogene. See also Mutation.
gene which normally directs cell growth, but when it becomes mutated, has the ability to transform a normal cell into a tumour cell through uncontrolled growth.
A mutant gene, usually related to cell cycle, that contributes to cancer development
gene that can cause normal cell s to become cancerous by effecting uncontrolled cell division.
Oncogenes play a role in cell growth and are normally found in cells. When an oncogene is damaged, it causes cells to grow too quickly and form tumors.
Genes that when inappropriately activated, contribute to the changing of a normal cell to a cancerous one.
ON-ko-jean A gene that normally controls cell division but when overexpressed leads to cancer. 183
a gene derived from a proto-oncogene, only one copy of which is necessary to cause cancer (e.g. RET gene mutation in MEN2)
gene that stimulates cancer cell growth
(OHN-ko-jeen) A gene that can transform the cell it is a part of into a
Cancer gene that is an activated or mutated form of a proto-oncogene.
A gene that can induce cancer.
A gene responsible for transformation of a cell to a cancerous phenotype. May occur through active induction of transformation, or by failing to repress transformation.
Gene that normally plays a role in the cell growth and division. When mutated, oncogenes can cause abnormal cell proliferation
a gene having the potential to cause (or facilitate) a normal cell to become cancerous
Genetic material normally present in cell (proto-oncogene) which has been triggered to cause uncontrolled cell growth.
A unit of DNA that normally directs cell growth, but which can also promote or allow the uncontrolled growth of cancer if damaged (mutated) by an environmental exposure to carcinog...
A gene that, when inappropriately activated, contributes to the malignant transformation of a cell
Literally means 'cancer gene'. Gene that has become abnormal and tells its cell to multiply continuously.
A gene of which one or more mutant forms is associated with cancer formation.
( on-koh-jeen) [Gk. onkos, tumor + genos, birth, race] A gene found in viruses or as part of the normal genome that is involved in triggering cancerous characteristics.
A gene that promotes the growth of cancer.
A gene coding for a protein that can contribute to the transformation of a normal cell into a tumor cell.
a gene (e.g., p53) that facilitates the development of cancer by regulating cell growth, either by actively "turning on" abnormal cell growth or failing to "turn off" normal cell growth.
Gene thought to be capable of producing cancer.
Genes that cause unregulated cell growth and proliferation. Oncogenes are present in viruses and in mammalian cells they are produced by a mutation. Before mutation they are called proto-oncogenes. These are constituents of the normal cell that code for growth factors.
An abnormal gene that causes a cell to grow in a uncontrolled manner and is responsible for tumor development.
a gene that causes uncontrolled cell proliferation
gene that normally directs cell growth but also can promote or allow the uncontrolled growth of cancer if damaged( mutated).
mutated gene that encourages a cancer to grow. In their unmutated form, most oncogenes are involved with the regulation of cell growth and the cell cycle.
Small pieces of genetic material capable of infecting animal cells and producing tumors.
Gene that when mutated or expressed at abnormally high levels contributes to converting a normal cell into a cancerous cell.
The part of the cell that normally directs cell growth, but which can also promote or allow the uncontrolled growth of cancer if damaged (mutated) by an environmental exposure to carcinogens, or if damaged or missing because of an inherited defect. A gene that has the potential to cause a normal cell to become cancerous.
a proto-oncogene that has been altered (mutated) such that it can promote tumor formation or cell growth.
Gene, expression (production of protein) of which causes cancer. These genes were originally found in cancer causing viruses where their presence was shown to be critical for producing cancer.
a gene that codes for a protein that is receptor or a part of a signal transduction pathway for a cellular growth factor. A mutated oncogene can transform a normal cell to a cancer cell.
A heredity unit that controls the growth of cancer cells.
a gene which is associated with the development of cancer.
Genes that normally play a role in the growth of cells but, when overexpressed or mutated, may foster the growth of cancer.
Mutated forms of genes (proto-oncogenes) which promote abnormal growth and cell division. Examples include KRAS, BCL1, and C-MYC which are involved in a range of different cancers.
A gene that has mutated, causing cells to become cancerous.
Many oncogenes are involved, directly or indirectly, in controlling the rate of cell growth. (IOGlossary) Oncogene Varmus e Bishop revelam a existência de oncogenes, genes dormentes capazes de causar câncer. (POUniverRS)
A gene that are capable or causing the transformation or normal cells into cancer cells.
Gene that contributes to cancer; e.g., HER2/neu
A gene, one or more forms of which is associated with cancer.
A gene that contributes to the production of a cancer. Oncogenes are generally mutated forms of normal cellular genes.
Any gene having the potential to induce cancerous transformation.
A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to cancer-causing agents.
A mutant gene that promotes uncontrolled cell growth once activated.
a gene that when altered in certain ways helps transform normal cells to cancerous cells
genes that promote cell growth and multiplication. These genes are normally found in all cells. But oncogenes may undergo changes that activate them, causing cells to grow too quickly and form tumors.
A gene that is capable of causing the transformation of normal cells into cancer cells. [ Talking Glossary
A gene whose product is involved either in transforming cells in culture or in inducing cancer in animals. Most oncogenes are mutant forms of normal genes (proto-oncogenes) involved in the control of cell growth or division.
An oncogene is a modified gene, or a set of nucleotides that codes for a protein, that increases the malignancy of a tumor cell. Some oncogenes, usually involved in early stages of cancer development, increase the chance that a normal cell develops into a tumor cell, possibly resulting in cancer.