A picayune was a Spanish coin, worth half a real. Its name derives from the French picaillon, which is itself from the Provençal picaioun, meaning "small coin". Besides being used in Spanish territories, it was also a common coin in the south of the United States, and the name has sometimes been used for the U.S. nickel, which was once worth approximately the same as a picayune.
The Picayune Amtrak Station, located in Picayune, Mississippi, is served by the passenger train. The street address is 100 South Highway 11, in the heart of downtown Picayune.