Strictly, a disease by pustules or eruptions of any kind, but chiefly or wholly restricted to three or four diseases, -- the smallpox, the chicken pox, and the vaccine and the venereal diseases.

a common venereal disease caused by the Treponema pallidum spirochete; symptoms change through progressive stages; can be congenital (transmitted through the placenta)

a contagious disease characterized by purulent skin eruptions that may leave pock marks

Pox is a liquor commonly used for ceremonial purposes among the Mayans of Mexico and Central America. It is made of sugarcane and is known in Spanish as aguardiente (Maffi 1996). The word pox in Tztotzil means "medicine, cane liquor, cure." http://titan.hum.sdu.dk:8080/Maya/FMPro Pox was commonly used in religious ceremonies and festivals in San Juan Chamula, Chiapas, but increasingly soda has been substituted for it.

To infect with the pox, or syphilis.