Medical procedure in which cells from an embryo conceived by in vitro fertilization are analyzed for genetic defects prior to implantation of the embryo in the mother's uterus. (73)
(PGD) A couple with a high risk for having a child with a particular genetic disease may opt for this procedure in conjunction with in vitro fertilization. PGD tests the embryos created during the IVF process for the genetic mutation(s) in question; only embryos free of the mutation are implanted. This is not yet possible for all diseases.
Genetic diagnosis by removing one or a few cells from an early embryo to test whether it is blighted with a harmful mutation or abnormal chromosome number. Abbreviated as "PGD" or "PD."
PGD is a technique used during in-vitro fertilization (IVF) to test embryos for genetic disorders prior to their transfer to the uterus. PGD makes it possible for individuals with serious inherited disorders to decrease the risk of having a child who is affected by the disorder. more info
Preimplantation genetic diagnosis (PGD) is a genetic test that can be carried out on embryos created using in vitro fertilisation (IVF), to ensure that only embryos unaffected by a particular genetic condition are returned to the woman's womb.
Technique used during In Vitro Fertilization procedures to evaluate the embryos for genetic or chromosomal abnormalities prior to their transfer into the uterus.
A method of testing IVF embryos for chromosomal or genetic disorders before they are transferred to the uterus; typically one or two blastomeres are removed for genetic testing at about the 8-cell stage of embryonic development.
A technique for screening embryos prior to implantation for genetic abnormalities. Only embryos free of such abormalities are implanted.
Use of genetic testing on one or two cells taken from a live early-stage embryo created by in vitro fertilisation. The procedure is usually carried out in order to determine whether the embryo is affected by a serious genetic disease. An unaffected embryo is implanted in the uterus and allowed to develop to term.
Genetic and chromosomal analysis of a cell taken from an embryo before transfer to the uterus.
A procedure performed in conjunction with IVF in which one or two cells are removed from an embryo prior to the initiation of pregnancy and screened for genetic abnormalities.
A method using DNA analysis to determine genetic information on an embryo before replacement.
Method of testing an in vitro embryo for disease relevant genes before transferring it into the uterus: cells are taken from the embryo during the 4 - 8 cell stage, normally three days after insemination (blastomere biopsy). At this point, each single cell still has the capacity to develop into an individual embryo (totipotency). Therefore, cells can be removed without damaging the embryo.
The genetic testing of an embryo prior to embryo transfer. One or two cells are removed from an embryo after 3 days of culture in a procedure called embryo biopsy and tested either for a specific genetic disorder (e.g., cystic fibrosis) or for an abnormal number of chromosomes (e.g., trisomy 21 - Down's syndrome). PGD is also performed for gender selection. (details)
A technique that involves examination of the chromosomes contained in the polar body, taken from an egg, or a blastomere from a developing embryo. Using a special technique, scientists and geneticists look for genetic abnormalities that can affect embryo implantation, contribute to miscarriage or cause genetic disease in offspring.
Techniques by which embryos fertilised in vitro are tested for specific genetic disorders (e.g. cystic fibrosis) or other characteristics such as sex before transfer to the uterus.
Examination of embryonic cells prior to implantation to determine whether the embryo will be genetically normal.
Combines two technically advanced procedures: in vitro fertilization or IVF and genetic analysis of single human embryo cells to identify the genetic disorders which occur naturally in embryos. PGD is of benefit to couples known to be at risk of passing an inherited disorder to their children and possibly in improving the likelihood of a successful pregnancy and birth following IVF.
a group of techniques used to detect genetic anomalies in embryos before transferring them into the uterus in the IVF process
A procedure done in conjunction with IVF that allows the selection and transfer of unaffected embryos and avoids the need for terminating an affected pregnancy after diagnosis at later stages of gestation. To analyze for the presence of a genetic defect, it is necessary to remove the first polar body of an unfertilized egg and/or a cell or cells from each embryo. This is called an egg or embryo biopsy and is usually done before insemination occurs, or 3 days after fertilization. Biopsy of one or two cells at the 8-cell stage does not adversely affect preimplantation development.
In medicine and (clinical) genetics preimplantation genetic diagnosis (PGD) is a considered an alternative to prenatal diagnosis. Its main advantage is that it avoids selective pregnancy termination as the method ensures a pregnancy free of the disease under consideration. PGD thus is an adjunct to assisted reproductive technology, and requires in vitro fertilization (IVF) to obtain oocytes or embryos for evaluation.