Spira, Spiro is Jewish family of scholars and rabbis originated from Speyer, Rhenish Bavaria, with numerous branches in other parts of Germany, and in Bohemia, Galicia, and Poland. It originally bore the name "Ashkenazi," to distinguish it from the Kahane or Katz-Spira family. Many prominent families of Bohemia added to their names that of "Spiro" or "Spira"; e.g., Frankl-Spiro, Wiener-Spiro, and Porges-Spiro.

The names Spira, Spiro, Shapira and Shapiro are derived from Speyer, a city in Germany, south of Mannheim on the Rhine river. Primarily associated with people of Jewish descent, the names "Spira" and "Shapira" (or "Spiro" / "Shapiro") are sometimes used interchangeably in genealogical records, due to the nearly identical Hebrew spelling, שפירא.

The fictional events of the Square Enix role-playing video games Final Fantasy X and Final Fantasy X-2 take place in a world called "Spira". As befitting its name, Spira is characterized by cycles and repetition, such as the spiral of death that the world endures, the many spheres found in Spira, the blitzball sphere pools, the prayer to Yevon, the Sphere Grid, and Spira's cycle of life energy emerging from within the planet's core, granting life to all its living inhabitants, and then returning to the core when a life form dies.Maechen: Ahem! The Farplane is the place where pyreflies born from a sending gather.