a normal gene whose protein products tell a cell not to divide/grow, or to stop in the cell cycle
A gene which suppresses the formation of tumors. Deletion or inactivation of this gene is believed to be required for tumour development.
A gene encoding a protein that suppresses tumor formation. The wild-type alleles of tumorsuppressor genes are thought to function as negative regulators of cell proliferation.
Protective gene that normally limits the growth of tumors. When a tumor suppressor is mutated, it may fail to keep a cancer from growing. BRCA1 and p53 are well-known tumor-suppressor genes.