A gene change in the body's reproductive cells (egg or sperm) that becomes incorporated into the DNA of every cell in the body of offspring; germline mutations are passed on from parents to offspring. Also called hereditary mutation.
Any mutation occurring in the germ line and transmitted to the offspring.
The presence of an altered gene within the egg or sperm (germ cell), such that the altered gene can be passed to subsequent generations Related Terms: de novo mutation ; germline ; germline mosaicism Related Terms: de novo mutation ; germline ; germline mosaicism
A gene change occurring in the reproductive cells (eggs or sperm).
See also: Hereditary-Mutation
An alteration in the genetic material of the body's reproductive cells (egg or sperm) that becomes incorporated in the DNA of every cell in the body.
(See Hereditary mutation.)
a change in the basic coding sequence of DNA that is inherited in all cells. Can be associated with an inherited disease (e.g., Huntington’s chorea) including rather rare forms of cancer (e.g.,breast cancer occurring in women that carry abnormal forms of the BRAC-1 and BRAC-2 genes).
A Germline Mutation is any detectable, heritable variation in the lineage of germ cells. Mutations in these cells are transmitted to offspring while those in somatic cells are not.