Design of a clinical trial that includes a balanced and randomized group of test subjects in terms of age and gender (where applicable), a control group following the same test protocol without actually receiving drug (placebo), and an independent review of the trial data. Trials may be open, blind or double-blind.
A prospective clinical trial comparing two or more treatments, or placebo and treatment(s) in similar groups of patients or within patients. A controlled trial may or may not use randomization to assign patients to groups, and it may or may not use blinding to prevent them from knowing which treatment they get.
Trials in which one group gets an experimental treatment and another gets either a placebo or an approved therapy. Participants do not usually know which group they are in.
a clinical trial in which the group receiving an experimental therapy is compared to a control group that is not given the intervention being studied. In a placebo-controlled trial the control group is given an inactive substance (placebo); in an active control trial the control group is given the best existing proven therapy. Contrast with uncontrolled trial. See also placebo-controlled trial.
A clinical study in which one group of participants receives an experimental drug while another group receives either a placebo or an approved standard therapy. When participants do not know which group they are in, the trial is blinded. See also Double-Blind.
Control is a standard against which experimental observations may be evaluated. In clinical trials, one group of participants is given an experimental intervention, while another group (i.e. the control group) is given either a standard treatment for the disease, a placebo or no treatment at all.
A trial in which subjects are assigned to a control condition as well as to an experimental condition.
a study in which a comparison is made between one treatment/prevention strategy and another. Sometimes one group receives an inactive agent: a placebo. Groups are usually randomised to one condition or the other. Both investigators and subjects usually do not know to which condition they have been randomised; this is called ‘blinding‚’.