Mefloquine is recommended for areas where malaria is chloroquine-resistant. Its functioning was still mysterious in 1994, and a wide range of conditions and side-effects (physiological and psychological) are given as pretexts for avoiding or discontinuing it's use. Many malaria-treatment drugs are also contra-indicated when taking Mefloquine. Treatment with increased dosages of Mefloquine is not recommended without close medical supervision. Treating malaria while on Mefloquine is possible with sulfa drugs (e.g. Fansidar), but these may be difficult or impossible to obtain in country. Considering Mefloquine? Consider the following. I am not a physician, parasitologist or pharmacologist. I did, however take mefloquine (brand-name "Lariam") as a malaria prophylaxis, and had to abandon it's use due to side-effects.

an antimalarial drug (trade name Larium and Maphaquine) that is effective in cases that do not respond to chloroquine; said to produce harmful neuropsychiatric effects on some people

A drug used against malaria.

Swiss-manufactured drug considered to be the most effective anti-malarial prophylaxis available for use in countries with Chloroquine-resistant malaria. Also known as Lariam.

an anti-malarial treatment.

Mefloquine is an orally administered antimalarial drug used as a prophylaxis against and treatment for malaria. It also goes by the trade name Lariam® (manufactured by Roche Pharmaceuticals) and chemical name mefloquine hydrochloride (formulated with HCl). Mefloquine was developed in the 1970s at the Walter Reed Army Institute of Research in the U.S. as a chemical synthetic similar to quinine.