Highest dose of a pesticide in chronic toxicity testing that is expected, on the basis of sub-chronic studies, to produce only limited toxicity when administered for the duration of the test period. (Duffus, 1993)
The highest dose of a chemical that does not shorten the organism's lifespan or cause severe damage to the organism.
The maximum amount of a chemical that can be fed to an experimental animal without incurring extreme health consequences such as death while continuing to produce some measurable toxic effect.
The highest dose of a drug or other treatment that most people can safely withstand.
The highest dose that can be administered to animals for two years without causing more than 10% loss of weight greater than controls or other evidence of significant systemic toxicity; the aim is to test chemicals at the highest dose feasible in laboratory animals, generally rats and mice.
The highest dose of an investigational drug that patients can tolerate without life-threatening or fatal side effects.
The highest dose that an organism can be exposed to without causing death or significant overt toxicity.
High dose used in chronic toxicity testing that is expected on the basis of an adequate subchronic study to produce limited toxicity when administered for the duration of the test period. It should not induce (a) overt toxicity, for example appreciable death of cells or organ dysfunction, or (b) toxic manifestations that are predicted materially to reduce the life span of the animals except as the result of neoplastic development or (c) 10% or greater retardation of body weight gain as compared with control animals. In some studies, toxicity that could interfere with a carcinogenic effect is specifically excluded from consideration
Highest dosage of a drug, drug combination or other treatment modality that patients can safely tolerate. Usually determined by Phase I Trial.
The maximum dose that an animal species can tolerate for a major portion of its lifetime without significant impairment or toxic effect other than carcinogenicity.