Seven United States Navy ships have been named USS Columbia, after the personification of the United States, also after the city of Columbia, South Carolina.

The first USS Columbia of the United States Navy was a 50-gun sailing frigate.

The sixth USS Columbia (CL-56) was a Cleveland class light cruiser of the United States Navy.

USS Columbia (SSN-771), a Los Angeles-class submarine, was the eighth ship of the United States Navy to bear that name. The earlier Columbias were given their names for differing reasons; SSN-771 was specifically named in honor of Columbia, South Carolina, Columbia, Missouri, and Columbia, Illinois. There are other Columbias in the United States; see that disambiguation page for a complete list.

The fourth USS Columbia (C-12/CA-16) was an unarmored cruiser in the United States Navy during the Spanish-American War and World War I. She was the lead ship of her class of two cruisers; her sister ship was Minneapolis (C-13). The class was originally designed with three funnels; variations at the yard resulted in Columbia being built with four and Minneapolis with two.