Acting against, or in a contrary direction; opposed; contrary; opposite; conflicting; as, adverse winds; an adverse party; a spirit adverse to distinctions of caste.

In hostile opposition to; unfavorable; unpropitious; contrary to one's wishes; unfortunate; calamitous; afflictive; hurtful; as, adverse fates, adverse circumstances, things adverse.

To oppose; to resist.

(adjective for vulnerability) = unfavorable.

Harmful or unfavorable.

contrary to your interests or welfare; "adverse circumstances"; "made a place for themselves under the most untoward conditions"

in an opposing direction; "adverse currents"; "a contrary wind"

adj. Opposing or opposed.

Adverse or adverse interest, in law, is an anything that functions contrary to a party's interest.