a metabolic disorder and does not involve the immune system

inability of the body to appropriately metabolize an agent or drug, often characterized by adverse side effects.

A general term which is used to refer to the condition afflicing people who exhibit a wide range of acute adverse effects. These include, but are not exhausted by, allergic effects.

inability to absorb or metabolize nutrients (e.g. lactose intolerance).

Refers to the inability of an individual to take a drug. Administration of this particular drug to the intolerant person results in the development of an adverse drug reaction ( side effect).