study of ADME processes (adsorption, distribution, metabolism, and excretion).
The handling of a drug within the body, including absorption, distribution in the body, metabolism, and excretion.
The study of the time course of a drug and drug metabolite concentrations in biological fluids, tissues and excreta.
The study of the bodily absorption, distribution, metabolism and excretion of drugs.
the study of how a drug is distributed in, and excreted from, the body.
Relationship between mechanisms of drug absorption, distribution and elimination over time.
The movement of a compound, usually a drug, in the body. A drug's pharmacokinetics are often determined by its uptake, distribution, solubility, metabolism and clearance rate.
how drugs are metabolized; how long they last and how high their levels, and how long they take to leave the body
distribution of a drug in the body and the rates of biotransformation. Kinetics information includes half-life, absorption, distribution, excretion, metabolism and analysis of body fluid levels.
quantitative study of how drugs are taken up, biologically transformed, distributed, metabolized, and eliminated from the body
Examination of the effects of the body on a drug, specifically examining issues such as how quickly a drug is absorbed into the blood and how different dosages affect the absorption, how the drug is distributed into organs or tissues the body, how the body metabolizes the drug and whether what the drug is changed into by the body is active, as well how long it takes the body to metabolize half of the drug (the drug's half-life), and how long it takes the drug to clear the body and be excreted.
The study of how the body absorbs, distributes, breaks down, and eliminates drugs.
The action of drugs in the body over a period of time, including the process of absorption, distribution, and localization in tissue, biotransformation, and excretion.
(FARM-ah-koe-kih-NEH-tiks) The characteristic interactions of a drug and the body in terms of its absorption, distribution, metabolism and excretion
The extent the body is able to absorb, distribute and eliminate a drug over time.
the properties of a drug with regard to absorption, distribution in the body, metabolism, and elimination
the study of how the body metabolizes a drug, which tissues the drug penetrates, its half-life, and other variables
the study of absorption, distribution, metabolism, and excretion of drugs (what the body does to the drug)
Studies that determine the action of a drug in the body over a period of time, including the processes of absorption, distribution, localization in tissues and excretion.
the process by which a drug is absorbed, distributed, metabolised and eliminated by the body.
the study of the action of drugs in the body: method and rate of excretion; duration of effect; etc.
How the body absorbs, handles, and gets rid of a medicine.
The movements and rate of movements of drugs within the body, including the impact of speed and degree of uptake, distribution, binding, elimination, and transformation to other drug forms.
The study of how drugs and potential drugs are absorbed, distributed, and finally eliminated from the body, in addition to how they are altered or broken down by the metabolism. Essentially, pharmacokinetics asks: How quickly is the drug taken up by the body, where in the body does it go, and how long does it stay there
study of the movement of a drug within a biological system, as affected by absorption, distribution, metabolism, and excretion
The action of drugs within the body.
The study of absorption, distribution, and elimination of bioactive compounds or drugs in or from the body.
the rate of movement of drugs within biological systems, as affected by uptake, binding, distribution and elimination
The patient's ability to handle a specific compound, as measured in terms of absorption, distribution, metabolism, and excretion. Pharmacokinetics and pharmacodynamics are directly related, because the ability of a specific compound to work at a specific site is dependent upon the pharmacokinetics of the individual compound. For example, if an antibiotic is active in vitro against common pathogens in pulmonary infections but the compound doesn't reach the lungs, then the pharmacokinetic parameters of the drug limit it's pharmacodynamic activity. In addition, inter-patient pharmacokinetic differences -- such as differences in absolute bioavailability, protein binding, and/or volume of distribution -- can also significantly alter the pharmacodynamic activity of a given compound.
The absorption, distribution, metabolism and excretion of a drug by the body, studied over a period of time.
The dynamic behavior of chemicals inside biological systems; it includes the processes of uptake, distribution, metabolism, and excretion.
study of the time course of drug and metabolite levels in different body fluids, tissues and excretions and includes drug absorption, distribution, metabolism and excretion. Metabolism of most chemotherapeutic drugs occurs mostly in the liver producing more toxic metabolites than the parent drug.
The pattern of absorption, distribution, and excretion of a drug over time.
The absorption, metabolism, distribution, and excretion of substances.
The processes (in a living organism) of absorption, distribution, metabolism, and excretion of a drug or vaccine.
The movements of drugs within biological systems, as affected by uptake, distribution, elimination, and biotransformation.
the study of the action of drugs in the body. It includes how the drug is used and gotten rid of, when it begins to act, and how long it acts. It also studies how the drug is changed into other things and what happens to its wastes.
the activity of drugs in the body over a period of time, including the processes of absorption, distribution, localization in tissues, biotransformation and excretion
The study of the absorption, distribution, metabolism and elimination of drugs in the body.
The study of the reactions between drugs or synthetic food ingredients and tissues and organs. Typically, pharmacokinetic studies measure absorption (ie, transport of the test substance into the bloodstream); distribution (ie, initial disposition, concentration, or behavior of the test substance in the body after it enters the body); metabolism (ie, the breakdown of the substance into other compounds and the ultimate disposition of those compounds; and elimination (ie, the speed and thoroughness with which the substance is excreted or otherwise removed from the body).
The study of drug absorption and metabolism.
The movement and rate of movement of drugs within a biological system, particularly uptake distribution, binding, elimination and biotransformation.
The study of how, and how quickly a drug distributes in the body and is eliminated is called pharmacokinetics.
Study of the absorption, distribution, metabolism, and excretion of chemicals and the genetic, nutritional, behavioral, and environmental factors that modify these parameters.
the study of the movement of medicines into, through, and out of the body
How the body handles a drug, including how it is absorbed, circulated, transformed, and eliminated. Pharmacokinetics are often the focus of Phase I trials.
The processes and rate at which a medicine passes through the body.
The study of the metabolism and action of drugs with particular emphasis on the time required for absorption, duration of action, distribution in the body and method excretion.
What happens to a drug when it has been administered: how it is absorbed, distributed, and excreted, from the body.
the action of drugs in the body, including the processes of absorption, metabolism, transformation, distribution to tissues, and elimination.
A mathematical model that expresses the movement of a toxic agent through the organ systems of the body to the target organ.
The processes of drug absorption, distribution, metabolism and excretion in a living system (e.g., in humans).Rapamycin (Rapamune, Certican): A drug that suppresses the immune system and is used to prevent rejection following organ transplantation.
How a drug is absorbed, distributed, metabolized and excreted in the human body.
The study of the movement of drugs within the body (i.e. the absorption, distribution via the blood, metabolism and excretion). The term is usually applied to medicines or therapeutic agents tested at doses related to their therapeutic action but can be applied to any xenobiotic chemicals. See also Toxicokinetics.
The study of how the body absorbs drugs, how they are distributed throughout the body, and how the body gets rid of drugs.
Process of the uptake of drugs by the body, the biotransformation they undergo, the distribution of the drugs and their metabolites in the tissues, and the elimination of the drugs and their metabolites from the body. Both the amounts and the concentrations of the drugs and their metabolites are studied. The term has essentially the same meaning as toxicokinetics, but the latter term should be restricted to the study of substances other than drugs. BT chemobiokinetics. PS toxicokinetics. RT biotransformation, pharmacokinetics
Study of how the body breaks down a drug after it is administered.
The study of how drug levels change over time in the body.
the study of the movement of a drug through the body, as affected by route of administration, uptake, distribution, elimination and biotransformation.
The study of the absorption, distribution, and elimination of alcohol and other drugs.
Term used in drug discovery to describe the testing (during lead optimization) a drug lead for its ability to produce some type of response. Drug leads found during screening may be able to bind in a highly specific fashion but if they produce no response in the body they are not very useful. Pharmacokinetic tests include the analysis of drug absorption, distribution, cross-reaction, metabolism, and elimination (urine).
The study of the time course of the concentration of a substance and its metabolites in body fluids like blood and urine.
pertaining to the movement of a drug within the body, particularly the rate at which absorption, distribution, metabolism and elimination occur.