Toxicity to nerve cells and processes resulting from too much activity.
An abnormal stimulation or activation of neurons in the brain and spinal cord that result in cell death. This stimulation is attributed to excess amounts of the neurotransmitter, glutamate.
A cascading cycle of neuronal injury and death in the central nervous system. Injured neurons release excessive amounts of glutamate which cause toxic levels of calcium flow into neighboring cells through NMDA receptor calcium channels. These cells swell and rupture, releasing more glutamate into the cellular environment (see "neuron" and "glutamate").
a neurological process that is the result of the release of excessive amounts of the neurotransmitter glutamate.
The over-stimulation of nerve cells by nerves. Excitotoxicity often leads to cell damage or cell death.
over stimulation of nerve cells by nerve impulses which results in excessive glutamate stimulation and calcium uptake into nerve cells leading to cell damage or death.
Cell damage due to excessive activation.
a damaging reaction mediated by the neurotransmitter glutamate which can be destructive and literally "excite" a neuron to death.
Overstimulation of nerve cells by nerve impulses. Excitotoxicity often leads to cell damage or death.
Toxic effects on target neurons, of excessive glutamatergic activity ( Ch. 29).
Excessive stimulation of a nerve cell by a neurotransmitter, which poisons the nerve cell and degrades it.
Excitotoxicity is the pathological process by which neurons are damaged and killed by the overactivations of receptors for the excitatory neurotransmitter glutamate, such as the NMDA receptor and AMPA receptor. Excitotoxins like NMDA and kainic acid which bind to these receptors, as well as pathologically high levels of glutamate, can cause excitotoxicity by allowing high levels of calcium ionsManev H, Favaron M, Guidotti A, and Costa E. Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.