Any of a group of enzymes that catalyze the transfer of a phosphate group onto tyrosine residues. These kinases play major roles in the cell signaling involved in cell division.
A protein that is involved with certain forms of cancer, including Ph+ CML. Medicine called tyrosine kinase inhibitors targets this enzyme as a treatment for Ph+ CML.
an enzyme that specifically phosphorylates tyrosine residues in proteins
an area within the human Epidermal Growth Factor Receptors (EGFRs) that is in charge of allowing cells to divide and multiply.
An enzyme involved in communication within cells, or signaling pathways. It is an abnormal tyrosine kinase that causes L.
Tyrosine kinases are a group of chemical messengers (enzymes) produced by body cells. TKs are part of the cell signalling system that tells cells when to divide and grow. Genes that control tyrosine kinase can be abnormal in cancer cells. The abnormal TK then sends too many signals to the cancer cell telling it to grow. Drugs that block tyrosine kinase can help to stop cancers from growing, for example imatinib (Glivec) and erlotinib (Tarceva).
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. Phosphorylation of proteins by kinases is an important mechanism in signal transduction for regulation of enzyme activity.