A drug whose actions result from its conversion by metabolic processes within the body.
An inactive drug precursor that is activated by a biological process, such as enzymatic cleavage.
Inactive forms of anti-cancer drugs. A prodrug of the anti-cancer drug melphalan is utilized in SGN-17/19, our research program based on the ADEPT technology platform.
An inactive or partially active drug that is metabolically changed in the body to an active drug.
A compound that must undergo chemical conversion within the body to change to its active form that has medical effects. Prodrugs are useful when the active drug may be too toxic to administer systemically, the active drug is absorbed poorly by the digestive tract, or the body breaks down the active drug before it reaches its target.
An inactive precursor drug which is converted to an active form, typically through cleavage by a cellular enzyme.
a chemically different but biologically similar form of a drug
a compound related to a drug that requires additional processing in the body before it becomes active
a compound that breaks down into the active agent
a drug that is administered in an inactive, or significantly less active, form and becomes an active pharmacological agent when it is metabolised in the body
a form of a drug which is inactive before metabolic processes in the body convert it into a usable form
a form that's given as a pill, injection, or other dose, but has to be metabolized by the body into another form before it can take effect
an inactive form of a drug that is converted within the body to a usable, or active, form
a pharmaceutical that turns into an effective drug inside the body
a pharmacologically inactive compound that is converted into a pharmacologically active agent by a metabolic transformation
a pharmacologically inactive compound that is converted to an active drug via a biological activation process that ideally takes place at the site of action
a pharmacological substance which is inactive until consumed and metabolized into an active compound
A compound that is converted within the body to its active, therapeutic form.
Any compound that undergoes biotransformation (chemical conversion) before exhibiting its pharmacological effects. Prodrugs can thus be viewed as drugs containing specialized protective groups used in a transient manner to alter or to eliminate undesirable properties in the parent molecule.
A compound that the body converts into active drug.
A pharmacological term applied to drugs that require some kind of metabolic action to be converted to a form that can be used by the body.
An inactive form of a drug; the drug is converted to its active form by processes in the body of the person that has taken it.
an inactive form of a drug that exerts its effects after metabolic changes within the body convert it to a usable or active form.
A compound that is converted within the body into its active form that has physiological effects. Prodrugs may be useful when 1) the active drug is too toxic to be administered systematically, 2) the active drug is absorbed poorly by the digestive tract, and 3) the body breaks down the active drug before it reaches its target.
A prodrug is a pharmacological substance (drug) which is administered in an inactive (or significantly less active) form. Once administered, the prodrug is metabolised in vivo into the active compound.