Definitions for "Genetic Heterogeneity" Add To Word List
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Similar phenotypes caused by mutations in more than one gene.
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The production of the same or similar phenotypes (observed biochemical, physiological, and morphological characteristics of a person determined by his/her genotype) by different genetic mechanisms. There are two types: (1) allelic heterogeneity -- when different alleles at a locus can produce variable expression of a condition; and (2) locus heterogeneity -- the term used to describe disease in which mutations at different loci can produce the same disease phenotype.
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Manifestation of similar or the same observable characteristics or traits (i.e., phenotype) resulting from different genetic mechanisms, such as changes (mutations) of different genes or a combination of genes.
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Process by which a phenotype can be caused by different loci. A complex example is epilepsy, which may be attributable to different causes in different individuals: single gene disorders, multifactorial inheritance, chromosomal disorders, or even brain injuries. The last case is a phenocopy.
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The phenomenon that a disorder can be caused by different allelic or non-allelic mutations.
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Refers to diseases, conditions or other characteristics that appear similar but whose genetic basis is different in different populations or individuals
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(1) The presence of different alleles at a gene locus. See Allelic diversity. (2) The ability of more than one allele to cause the same trait, for instance, a disease. Alleles at different gene loci (locus heterogeneity), as well as those at the same locus (allelic diversity), may each be expressed as the same trait.
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Mutations in different genes produce a clinically similar picture
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Similar phenotypes produced by different genetic mechanisms.
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when different genes produce identical phenotypes (e.g., bleeding disorders)
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