Inactivation of specific genes. Knockouts are often created in laboratory organisms such as yeast or mice so that scientists can study the knockout organism as a model for a particular disease.
An alteration of a gene that results in loss of function; a transgenic organism in which a gene has been inactivated.
The deletion or deactivation of a gene in a mouse or other laboratory animal to create a line of animals that are incapable of producing the gene product.
An informal term for a mutant organism (generally a mouse) in which a specific gene has been "knocked out." Usually, the animal is genetically engineered to contain a null allele of a gene under study.
Deactivation of specific genes; used in laboratory organisms to study gene function.
in genetics, a cell or organism from which a given gene has been disrupted experimentally; "double knockout", from which two selected genes have been disrupted.
A cell or model organism in which one or more genes have been "knocked out," or inactivated, in order to study what the gene does. Model organism knockouts, especially mice, are useful for studying human disease.
Inactivation of the gene by homologous recombination following transfection with a suitable DNA construct.
The process by which genes are made inactive in a laboratory. Scientists often use knockouts in mice in order to study what effect the inactivity of a given gene will have on the animal.
The changing of a gene so that that organism loses a specific characteristic.
Informal term for the generation of a mutant organism in which the function of a particular gene has been eliminated.
An animal whose endogenous gene for a particular protein has been deleted or mutated to be non-functional.
Refers to an organism that has a particular gene or trait purposely removed by selective breeding or laboratory techniques (e.g., a huntingtin knockout mouse).