loss of structural differentiation within a cell or group of cells often with increased capacity for multiplication, as in a malignant tumor.

Loss of a cell's differentiated state, or reversion to a more "primative" cellular phenotype. This usually is seen in association with cancer cells.

Changes occurring among groups of cancerous cells or within an individual cancer cell.

Loss of normal cell differentiation, a feature characteristic of most malignancies. RT malignancy.