An acute malignant contagious fever, that often prevails in Egypt, Syria, and Turkey, and has at times visited the large cities of Europe with frightful mortality; hence, any pestilence; as, the great London plague.

A serious infectious disease spread to humans by fleas from rats and mice

infectious disease or epidemic from which many people die

epidemic-type illnesses; i.e., the London Plague, which occured in "great" epidemics in 1563, 1593, 1603, 1625, 1665 (and "lesser" epidemics, including in the year 1609. (Ref: Plague in London: Spatial and Temporal Aspects of Mortality by Graham Twigg

That which smites, wounds, or troubles; a blow; a calamity; any afflictive evil or torment; a great trail or vexation.

To infest or afflict with disease, calamity, or natural evil of any kind.

any large scale calamity (especially when thought to be sent by God)

To dream of a plague raging, denotes disappointing returns in business, and your wife or lover will lead you a wretched existence. If you are afflicted with the plague, you will keep your business out of embarrassment with the greatest maneuvering. If you are trying to escape it, some trouble, which looks impenetrable, is pursuing you. Plain. For a young woman to dream of crossing a plain, denotes that she will be fortunately situated, if the grasses are green and luxuriant if they are arid, or the grass is dead, she will have much discomfort and loneliness. See Prairie.