The 1933 Major League Baseball All-Star Game was the first playing of the midseason exhibition baseball game between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 6, 1933 at Comiskey Park in Chicago, the home of the Chicago White Sox of the American League. The game resulted in the American League defeating the National League 4-2.