Definitions for "Abnormal spindle-like microcephaly-associated protein"
concentrated at mitotic spindle poles in embryonic neuroepithelial cells (progenitor cells of the brain) and down-regulated when they switch from proliferative to neurogenic divisions. Protein is associated with determining human cerebral cortical size, possibly by maintaining symmetric cleavage plane orientation in neuroepithelial cells during brain development. (More? Neural Notes | Neural Abnormalities | OMIM ASPM | Fish JL, Kosodo Y, Enard W, Paabo S, Huttner WB. Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A. 2006 Jun 23)