Aenesidemus was a book published anonymously by Professor Gottlob Ernst Schulze of Helmstedt in 1792. Its complete title was Aenesidemus or Concerning the Foundations of the Philosophy of the Elements Issued by Professor Reinhold in Jena Together with a Defense of Skepticism against the Pretensions of the Critique of Reason. The book was supposed to be a written correspondence between Hermias, who believes in the Kantian critical philosophy, and Aenesidemus, who is skeptical about that philosophy.

Aenesidemus, Greek philosopher, was born at Cnossus in Crete and taught at Alexandria, probably during the first century BC.