Derailed is a thriller novel written by James Siegel and published in February 2003. It tells the story of Charles Schine, a man who works in the advertising business, who suddenly finds himself having an affair, being blackmailed, and having the police investigate him for murder, all because he missed his usual commuter train one day.

Derailed is a 2005 American thriller/drama film based on a James Siegel novel by the same name adapted by Stuart Beattie. The film is directed by Mikael Håfström and stars Clive Owen, Jennifer Aniston and Vincent Cassel.

Derailed is a 2002 action movie directed by Bob Misiorowski and starring Jean Claude Van Damme and Tomas Arana.

Derailed (aka Snow Job) is expected to be the sixteenth espisode from the dramedy series Ugly Betty.