Definitions for "Sister chromatid exchange"
Reciprocal exchange of chromatin between two replicated chromosomes that remain attached to each other until anaphase of mitosis; used as a measure of mutagenicity of substances that produce this effect. RT mitosis.
(synonym: SCE) Exchange of genetic material between the two chromatids of a single chromosome during the cell division process; similar to crossing-over (recombination), except that the exchange involves the two sister chromatids of a single chromosome, whereas crossing-over refers to exchange of genetic material between the two homologous chromosomes of a chromosome pair
Sister chromatid exchanges (SCEs) involve breakage of both DNA strands, followed by an exchange of whole DNA duplexes. SCE analysis is considered to be a sensitive method for detecting DNA damage. [See: Evidence Supporting the Mutagenicity of Fluoride | Micronucleus and Sister Chromatid Exchange Frequency in Endemic Fluorosis