referring to inheritance of a genetic trait; a trait that is expressed whenever the gene is present and unrelated to the sex of the individual

'Autosomal' refers to a non-sex chromosome. Autosomal dominance is when one particular form of a gene, one allele, dominates over other alleles and is always expressed when present in an individual whether they are homozygous for that allele or heterozygous.

inheritance pattern where only 1 of the gene pair is needed to cause the trait in question. The disease-causing gene can be inherited from an affected parent or arise as a new mutation. (Autosome means the gene is carried on a non-sex-determining chromosome—1 of 22 chromosome pairs that are the same in males and females.)

autosomal is the name given to a gene or group of genes that are not situated in the sex chromosomes. If a genetic feature is dominant, it will always be expressed and will not be hidden by the opposite gene.

A dominant allele whose gene is located on an autosome.

describes a trait or disorder in which the condition is expressed in those who have inherited one copy of a particular gene mutation; individuals with an autosomal dominant condition have a 50% chance to pass the condition to each offspring

Describes a type of inheritance where an individual with a mutation in only one copy of a gene will develop the associated trait or disorder.

genetic disorder in which every child of a sufferer has a 50% chance of inheriting the disorder Back to the top

AW-toe-soe-mal DOM-i-nent An allele that masks the expression of another allele. 267

Autosomal dominant inheritance means that the gene involved is not on one of the sex chromosomes and so males and females have the same chance of being affected. It also means that a person only needs to have one changed gene before they have the disorder. The normal gene is not able to make up for the gene with a change in it. If a child is affected but neither parent is affected, it is likely that the gene change happened for the first time in the child. When a person with an autosomal dominant disorder has children, they may either pass on the normal gene or the changed gene. There is no way to control which gene is passed on. View a diagram which shows autosomal dominant inheritance when only one parent is affected.

Autosomal dominant inheritance refers to genetic conditions that occur when a mutation is present in one copy of a given gene (i.e., the person is heterozygous).

A mode of inheritance in which a gene is passed on by either parent; in most cases, the child has a 50% chance of inheriting the gene; the expression of the gene (that is, the development of the physical trait or the disorder) can vary considerably among different individuals with the same gene.

mode of transmission of a hereditary disease in which the patient received a chromosome from a sick parent bearing the gene anomaly. The involvement of only one parent by the disease is sufficient to transmit the disease to the child with a risk of 1/2 (50%) at each pregnancy.

Autosomal dominant means that only one copy of a gene, inherited from either the mother or the father, needs to have the mutation for the child to have the disorder. All of the chromosomes except the sex chromosomes are autosomes.

Individuals possessing one copy of a mutation on an autosomal chromosome will be affected.

A gene on one of the non-sex chromosomes that is always expressed, even if only one copy is present. The chance of passing the gene to offspring is 50% for each pregnancy.

Describes a trait or disorder in which the phenotype is expressed in those who have inherited only one copy of a particular gene mutation (heterozygotes); specifically refers to a gene on one of the 22 pairs of autosomes (non-sex chromosomes) Related Terms: de novo mutation ; germline mosaicism ; heterozygote ; mode of inheritance ; penetrance ; variable expressivity

a trait (or a disease) that is produced when only one copy of a gene is present

A gene on one of the autosomes that, if present, will almost always produce a specific trait or disease. The chance of passing the gene (and therefore the disease) to children is 50-50 in each pregnancy.

a person who is affected possesses one copy of a normal allele and one copy of a mutant allele. This person has a 50-50 chance of passing along the mutant allele

A characteristic or disorder that is expressed in the heterozygote (requires only one altered copy of a gene to result in the expression of the characteristic or disorder).

describes a genetic condition in which the defective gene is dominant and is inherited by 50% of the offspring of either sex

A pattern of Mendelian inheritance whereby an affected individual possesses one copy of a mutant allele and one normal allele. (In contrast, recessive diseases require that the individual have two copies of the mutant allele.) Individuals with autosomal dominant diseases have a 50-50 chance of passing the mutant allele and hence the disorder onto their children. Examples of autosomal dominant diseases include Huntington's disease, neurofibromatosis, and polycystic kidney disease.

A pattern of inheritance in which only one of the two copies of an autosomal gene must be abnormal for a genetic condition or disease to occur. An autosomal gene is a gene that is located on one of the autosomes or non-sex chromosomes. A person with an autosomal dominant disorder has a 50% chance of passing it to each of their offspring.

A gene on one of the non-sex chromosomes which manifests in the heterozygous state.

a term describing a gene on any chromosome other than the sex chromosomes that produces its effect whenever it is present; can also describe the effect of the gene itself

An autosomal dominant gene is one that occurs on an autosomal (non-sex determining) chromosome. As it is dominant, the phenotype it gives will be expressed even if the gene is heterozygous. This contrasts with recessive genes, which need to be homozygous to be expressed.