Definitions for "Chemokines"
Related family of proteins produced by many mammalian cell types that mediate chemotaxis and organize activities of cells of specfic and non-specific defenses (Lecture: Innate Immunity and Inflammation II, 2/21/02)
chemokines are signaling molecules that attract immune cells to infected cells. Some examples of chemokines are MIP-1a, MIP-1b,and RANTES. Chemokines have been found to bind to a corecptor for the HIVvirus that is on the surface of macrophages.
A large family of structurally homologous, low molecular weight cytokines that stimulate leukocyte movement and regulate the migration of leukocytes from the blood to tissues (1).