the calcium salt of folinic acid. Leucovorin is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the -isomer, known as Citrovorum factor, or -folinic acid. The terms leucovorin and folinic acid generally are used interchangeably. However, the leucovorin product available in the United States is the racemic mixture (ie, contains equal amounts of -folinic acid and -folinic acid). When -folinic acid is used, it is administered at half the dose of leucovorin (the racemic mixture).

a derivative of folic acid, a member of the vitamin B complex. Leucovorin protects cells from the cytotoxic effects of certain drugs (e.g., dapsone, trimetrexate) and is used to prevent drug-induced anemia.

Folinic Acid. Commonly used in combination with other chemotherapies.