A laboratory measurement of biological activity within the body that indirectly indicates the effect of treatment on disease state. CD4 cell counts and viral load are examples of surrogate markers in HIV infection.
A substitute; a person or thing that replaces another. In HIV disease, the number of CD4+ T cells and CD8+ cells is a surrogate immunological marker of disease progression. See also CD4 (T4) or CD4+ Cells; CD8 (T8) Cells.
An indirect indicator of something, such as measuring viral load to assess the treatment effect of a drug.
Laboratory tests that may predict a patient's clinical outcome or indicate whether a drug is effective without having to rely on the traditional clinical endpoints of death or development of a major opportunistic infection. See CD4 (T4) or CD4+ Cells; CD8 (T8) Cells.
A parameter that is measured to assess progression of a disease or outcome of a treatment that is only indirectly relevant to the patient's health. An example would be the number of cancerous cells in the patient's blood
Laboratory tests that may predict a patient's clinical outcome or indicate whether a drug is effective without having to rely on the traditional clinical endpoints of death or development of a major opportunistic infection. Surrogate markers under study in HIV disease include CD4 counts, CD4/CD8 cell ratios, and viral load.
an indirect measure of disease progression. In HIV disease, the number of CD4+ T cells per cubic millimeter of blood is often used as a surrogate marker.
a marker or sign that can serve in place of a clinical endpoint such as such as the disease progression or death. Surrogate markers for HIV disease may virologic (e.g., viral load), immunologic (e.g., CD4 cell count) or clinical (e.g., weight loss).
A variable that provides an indirect measurement of effect in situations where direct measurement of clinical effect is not feasible or practical.
