An intracellular second messenger synthesized by the enzyme guanylyl cyclase from GTP.

Cyclic guanylate monophosphate (cyclic GMP) is produced from guanylate triphosphate (GTP) via the enzyme guanylate cyclase. Cyclic GMP has numerous actions as an intracellular signalling molecule, including relaxation of smooth muscle. The vasodilatory effect of NO on smooth muscle is mediated by the production of cyclic GMP by guanylate cyclase.

The intracellular signalling molecule cyclic guanosine monophosphate. It is generated by the hydrolysis of guanosine triphosphate (GTP) by G-protein-dependent guanylyl cyclase.