Shadwell is an inner-city district in the London Borough of Tower Hamlets located on the north bank of the Thames between Wapping to the west and Limehouse to the east. It is located 3 miles (4.8 km) east of Charing Cross and forms part of the East End of London.

Shadwell, a plantation in Virginia near Charlottesville, was the birthplace of Thomas Jefferson. It was named after Shadwell parish in London where his mother Jane Randolph was born. In 1770, the house at Shadwell was destroyed in a fire and the family of Peter Jefferson moved to a home called Edge Hill.