A condition in which myeloma light chains (Bence Jones proteins) are deposited in tissues and organs throughout the body. This occurs more commonly with lambda versus kappa Bence Jones proteins. In patients with amyloidosis, the light chain proteins bind to certain tissues such as heart, nerves and kidney rather than being excreted out of the body through the kidneys.

A condition in which a protein-like material builds up in one or more organs. This material cannot be broken down and interferes with the normal function of that organ. People who have been on dialysis for several years may develop amyloidosis because dialysis fails to filter this protein-like material out of the blood.

Condition whereby a myeloma patient's light chains can form amyloid protein, a starch-like substance. Amyloid protein can accumulate in various tissues and organs, disrupting their normal functions. Amyloidosis can also occur in people who do not have myeloma.

a pathologic condition in mated queen honey bees (Hymenoptera: Apidae), causing premature drone production, associated with the deposition of amyloid in the cytoplasm of the spermathecal epithelium of the affected queens (Steinhaus and Martignoni).

A group of diseases that result from the abnormal deposition of a protein called amyloid in tissues and organs.

a fatal disease with no treatment available and we are on target for the commercialization of this product late next year

a progressive and fatal condition that occurs in a proportion of patients with chronic inflammatory diseases, including RA, ankylosing spondylitis, juvenile rheumatoid arthritis, and Crohn's disease

a progressive and fatal condition that occurs in a proportion of patients with chronic inflammatory disorders, chronic infections and inherited diseases such as Familial Mediterranean Fever

a rare disease that is a consequence of chronic inflammatory diseases like rheumatoid arthritis and Familial Mediterranean Fever and frequently progresses to end-stage renal failure and death

a serious and potentially fatal complication of Crohn's disease

a severe disease

Disorder in which the body deposits a certain type of protein in a variety of tissues. The deposits may cause the growth of benign masses. The cause of this disorder is unknown.

Deposition of an eosinophilic, Congo red positive proteinaceous material between cells in various tissues of the body and in a variety of clinical settings.

Amyloidosis is the term for a group of conditions in which an abnormal substance called amyloid is deposited throughout the body. The term means "starch-like." In one form of amyloid, malignant plasma cells, sometimes in association with other manifestations of multiple myeloma, deposit portions of immunoglobulin molecules referred to as light chains, in tissues. These light chain deposits are the amyloid in this circumstance. In the type of amyloid that occurs in myeloma or closely related diseases, organ failure can occur as a result of amyloid deposits in the heart, gastrointestinal tract, and other systems.

a rare disease which causes the build-up of amyloid, a protein and starch, in tissues and organs.

A disorder that results from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Amyloid protein can be deposited in a localized area and not be harmful, or it can cause serious changes in virtually any organ of the body.

A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition. As the AMYLOID deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

abnormal deposit of a waxy substance (amyloid) in tissues or organs

The build up of amyloid to a degree that it causes damage to the tissues or action of those tissues in the body.

A disease in which excessive protein is deposited around cells in various organs and tissues of the body.

A genetic disease, often resulting in renal (kidney) failure.

Accumulation of amyloid deposits in various organs and tissues in the body such that normal functioning of an organ is compromised.

A rare condition in which certain blood cells produce an abnormal protein that deposits in the tissues. If the deposits are in the heart, heart failure can result.

A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause) or secondary (caused by another disease, including some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often effects the spleen, kidneys, liver, and adrenal glands.