Cancer that is growing, spreading, or getting worse.
Myeloma disease that continues to progress despite therapy (ie, a greater than 25% increase in M protein, new bony lesions, or a new plasmacytoma). Relapsed and/or refractory disease can be considered to be progressive disease.
Progressive disease is defined in clinical trials as tumor growth of more than 20 percent since treatment began. Tumor growth means that the tumor is getting bigger, but it may also mean that the tumor is spreading. Progression generally indicates that treatment has stopped working.
Cerebral palsy is not a progressive disease. That is, it does not get worse over time. Different symptoms, however, may become apparent as the child ages.
advancing as a disease from bad to worse. A progressively debilitating condition. (Link to Multiple Sclerosis, Parkinson's, Alzheimer's)
Cancer that continues to grow after treatment has begun. In order to qualify for this, the growth must be at least 20%. The bottom line here is that either the tumor has gotten larger or the cancer has spread to other areas. Neither case is good news. The course of action you have chosen is not working.
a disease that continually increases in severity.
Disease is getting worse as documented by tests showing that tumors are growing or that new tumors are appearing.
Disease that worsens during or after therapy because the cancer cells continue to grow. In lymphoma, symptoms of progression may include increasing size in a number of lymph nodes; symptoms of local obstruction by a swollen lymph node; fever, weight loss, and profound fatigue; and or a decline in blood counts.
Term applied when disease is worsening, documented by tests showing that the tumor is growing or than additional tumors have appeared. Some trials are limited to patients with progressive disease so that if improvement occurs it can be assumed to be the result of the investigational therapy.