HUMAN LEUKOCYTE ANTIGENS. A protein that is found on cells that must be matched between a donor and a transplant recipient before a transplant can take place. PLASTICITY: The ability to which a stem cell can be manipulated into becoming another type of cell.

see Human Leukocyte Antigens

the transplantation antigens (i.e., the antigens that are the major targets of rejection) of humans. These molecules have a role in regulating the immune response in general. There is a correlation between certain HLA antigens and certain diseases such that people with those HLA antigens are at higher risk for those diseases.

The acronym for human leukocyte antigens. These proteins are on the surface of most tissue cells and give an individual his or her unique tissue type. HLA factors are inherited from mother and father and the greatest chance of having the same HLA type is between siblings. On average one in four siblings is expected to share the same HLA.type. The testing for HLA antigens is referred to as “tissue typing.” There are six major groups of HLA antigens A, B, C, D, Dr, and Dq. These proteins on the surface of cells act as antigens when donated (transplanted) to another individual, the recipient. If the antigens on the donor cells are identical (e.g. identical twins) or very similar (e.g. HLA matched-sibling) the transplant (donated stem cells) are more likely to survive (engraft) in the recipient. In addition, the recipient's body cells are less likely to be attacked by the donated immune cells (graft versus host disease).

(H-L-A) Human lymphocyte antigen. The major antigen compatibility complex in humans that is genetically determined and is involved in cell self-identification and histocompatibility.

Human Leukocyte Antigens. a set of 6 antigens used to match a blood or bone marrow donor to a recipient. These antigens appear on white blood cells as well as cells of almost all other tissues and are analogous to red blood cell antigens (type A, B, O, etc.) By typing for HLA antigens, donors and recipients of white blood cells, platelets, and organs can be matched to ensure good performance and survival of transfused and transplanted cells.

These are molecules on the surface of human cells that determine a person's white blood cell type. Ten numbers make up this system. There are two A numbers, two B numbers , two C numbers, two DR numbers and two DQ numbers. One number at each locus (A,B,C, DR and DQ) comes from your mother the other one comes from your father. Couples with infertility and recurrent pregnancy losses share too many DR and DQ HLA factors. They are too compatible. This is referred to as the unlucky match for a successful pregnancy to occur.

Human Leukocyte Antigens (used in the typing for BMT) "

Human leucocyte (white blood cell) antigens that are related to the workings of the immune system.

Antigens found on a person's cells that help the body to identify its own cells from invading or foreign cells.

Human leucocyte antigens. These are cell surface proteins, detected by blood testing, that vary from person to person. They are also called tissue antigens or histocompatibility antigens because ideally organ donors and recipients must have compatible HLA; otherwise the transplanted organ is recognized as nonself ('foreign') and is rejected. HLA are related to the workings of the immune system; they present selfand foreign-derived (e.g. viral) peptides (a few amino acids linked together) to T lymphocytes and other cells of the immune system that help the body fight illness. They are of two broad types, called class I and class II HLA. Their genes are located on chromosome 6; the loci are given the letters A, B, C, D, and so on.

The transplantation antigens (i.e., the antigens that are the major targets of rejection) of humans. HLA characteristics determine immunity - the ability to recognize foreign or "non-self" antigens. The wider the differences in the HLA characteristics of donor and recipient, the greater the chance of organ rejection.

Abbreviation for human leukocyte antigen. A genetic fingerprint on white blood cells and platelets, composed of proteins that play a crucial role in activating the body's immune system to respond to foreign bodies.

markers on the surface of a body's cell that identify the cell as one's own (as opposed to a foreign cell) and prevent the immune system from attacking itself.

Human leukocyte antigen; the HLA system is very complex and characterised by extreme polymorphism. There are many websites dealing with HLA or Mhc (Major histocompatiblity complex), among them http://syfpeithi.de where you will also find references to further interesting links to HLA.

human lymphocyte antigens; system designation for the gene products of at least four linked loci and a number of subloci on the sixth human chromosome which have a strong influence on human allotransplantation, transfusions, and certain disease associations ( see antigen)[close window

Human Leukocyte Antigens. The system for determining and identifying a person's antigen makeup (before kidney and pancreas transplants).

Abbreviation for human leukocyte-associated antigen.

acronym for human leukocyte antigen

human leukocyte antigen. a system of cell surface antigens which induce and regulate the immune response. HLAs are used to match body tissues for organ transplants.

Human Leukocyte Antigen. A genetic fingerprint on white blood cells and platelets, made up of proteins that play a critical role in activating the body's immune system. If two individuals have indentical HLA types, they are said to be histocompatible.

abbreviation, see human leukocyte antigen.

human leukocyte antigens, which are marker molecules on the surface of cells that identify cells as "self" and prevent the immune system from attacking them.

Human leukocyte antigens. MHC molecules expressed on the surface of human cells human MHC were first identified as alloantigens on the surface of white blood cells leukocytes) that bind serum antibodies from individuals previously exposed to other individuals' cells. (e.g., mothers or transfusion recipients) (1).

Human leukocyte antigens. The proteins present on the surface of the white blood cell, and most other cells of the human body, which allow the body to recognize self versus nonself. HLA A, B, and DR are important in BMT.

Human leucocyte antigen. Any human Class I and Class II major histocompatability complex (MHC) protein. These are important in presenting antigens to immune effector cells

Genetic markers found on the surface of leukocytes

Human leukocyte antigen. A blood test used to match a blood or bone marrow donor to a recipient for transfusion or transplant.

Human-leukocyte-antigen system. See major histocompatibility antigens.

Human leukocyte antigens. A set of genes specific to the immune system that ideally should match when someone has an organ transplant. Certain HLA types can predispose individuals to develop particular diseases, especially autoimmune diseases. For example, HLA class II gene DRB1*0402 is recognized in people with Pemphigus Vulgaris.

human leucocyte antigen - the name for the molecules which have to be matched between the donor and the patient. These molecules exist in many very similar but different forms.

a form of serologic and molecular testing to identify 6 genetic markers on blood cells. The donor needs to match at least 3 out of 6 antigens to be considered a match.

human leukocyte antigens or human MHC.

human leucocyte antigens which are natural markers on white cells much the same as blood groups on red cells

Human leucocyte antigen system.

two major classes of molecules on cell surfaces.

Human Leukocyte Antigen. A distinguishing series of proteins that exist on the surface of every white blood cell to help the cells discriminate between “friendly” cells and “foreign” matter like bacteria and viruses. HLA “matching” plays a vital role in allogeneic, or unmatched, bone marrow and stem cell transplants.

Human Lymphocyte Antigene. One of the histocompatibility genes used to determine if donor organs are compatible. - Antigen responsible for rejection of tissue transplants and correlated with specific diseases, including MS. - Antigens that, when combined with antigenic peptides, cause T-cells to launch an attack.

Human leukocyte antigens. Protein in markers of self used in histocompatibility testing. Some HLA types also correlate with certain autoimmune diseases.

(Human leukocyte antigen) A diverse group of human cell surfaces molecules that play important roles in cellular immunity.

Human Leukocyte Antigens, of which there are several major genetically controlled groups: HLA-A, HLA-B, HLA-C, and HLA-DR. It is important to identify and match the HLA type of a donor and a potential kidney recipient.

Human Leukocyte Antigens. Proteins on white blood cells that make each person's tissue unique. The HLA A, B, C and DR proteins are important in matching patients and donors for a marrow or blood stem cell transplant.

Human lymphocyte antigen. One of a group of proteins found on the surface of white blood cells and other cells that play an important part in the body's immune response to foreign substances. These antigens vary from person to person, and an HLA test is done before organ transplantation to find out if tissues match between a donor and a recipient. Also called human leukocyte antigen.

Human leukocyte antigen. a type of receptor on cells involved in recognising foreign antigens; some are associated with different types of arthritis

Human leukocyte antigen, one of four genetic markers used to assess tissue compatibility.

Proteins located on the surface of the white blood cells and other tissues in the body. (pg. 2).

human leukocyte antigen. See MHC protein.

HUMAN LEUKOCYTE ANITGENS. Markers that identify cells as "self" and prevent the immune system from attacking them.

Human Leukocyte Antigens, nomenclature designating MHC in humans.

The major human histocompatibility system. HLA-typing is done before transplantation to determine the degree of histocompatibility. HLA is an acronym for Human Leukocyte Antigens. See the entire definition of HLA

The human major histocompatibility complex.

Abbreviation for "Human Leukocyte Antigens". This describes tissue characteristics. These are pre-determined in the genotype. The HLA typing is important for the preparation of allogenic transplants. The greater the similarity of donor organ and recipient organ, the greater the chance of a successful stem cell transplant.

Antigens present on the cell surfaces of various tissues, including leucocytes.