The game pits one person against 100 others for a chance to win a large cash prize. Players are asked questions of the multiple choice variety each with three possible answers. The gameshow is a variation of the show Eén Tegen Honderd, a Dutch gameshow produced by Endemol and sponsored by the National Postcode Lottery.

The American version of 1 vs. 100 is broadcast by NBC. Like in other formats, a single player goes up against 100 other contestants (referred to as the "mob"), gaining money for each contestant they eliminate but losing all their winnings with any incorrect answer along the way. The host is actor-comedian Bob Saget, and the top prize is $1,000,000 (US$, before income tax deductions).

Australian game show that is based on the American game show of the same name and the format created by Endemol. The game pits one person against 100 others for a chance to win one million dollars. The program is hosted by Nine Network CEO and personality Eddie Mc Guire.