Cuyo is the name given to the wine-producing, mountainous area of central-west Argentina. Historically it comprised the provinces of San Juan, San Luis and Mendoza. Nuevo Cuyo (New Cuyo) region also includes La Rioja, though it is generally referred to as Cuyo.

Cuyo is a Puyo Puyo-style puzzle game for up to two players. The player controls falling blocks of various types which change with each level. For example, in the first level, the player has to connect differently colored cartoon faces to each other.