Definitions for "Nonsense mutation"
Related Terms:
Genetic code, Codon, Degeneracy, Stop codon, Transfer rna, Trna, Missense mutation, Translation, Protein synthesis, Start codon, Initiation complex, Nucleoprotein, Anticodon, Reading frame, Nucleic acid, Biomolecules, Nucleotides, Oligonucleotide, Messenger rna, Nucleic acids, Peptidyl transferase, Dna, Mrna, Nonsense codon, Rna, Polynucleotide, Nucleotide, Orf, Triplet code, Ribonucleic acid, Deoxyribonucleic acid, Bases, Rrna, Ribosome, Nuclease, Ligase, Ribosomal rna, Open reading frame, Denaturation, Exonuclease, Aptamer, Nucleoside, Polymerase, Leader sequence, Endonuclease, Rna polymerase, Post-translational modification, Cytosine, Base, Guanine
A mutation that causes the formation of a nonsense codon and the truncation of the protein product.
A mutation in which a codon is changed to a stop codon, resulting in a truncated protein product.
a mutation in which one of the three terminator codons (used to signal the end of a polypeptide) in messenger RNA appears in the middle of a genetic message, causing premature termination of transcription, resulting in the production of generally nonfunctional polypeptides.
A mutation that changes an amino acid specifying codon to one of the three termination (stop) codons.
Nucleotide substitution that creates a stop codon. ATG GTG AA GTA... (MetValLysVal...) to ATG GTG AA GTA would result in a truncated protein (MetVal), most likely to be non-functional
A mutation which converts an amino-acid-specifying codon into a stop codon, e.g., a change from UAU (tyr) to UAG (amber) would lead to the premature termination of a polypeptide chain at the place where a tyrosine was inserted in the wild-type. See stop codon; suppressor.
Mutations that change a codon for an amino acid to one of the codons (UAG, UAA, or UGA) that signal termination of translation. The resulting gene product is a shortened polypeptide that begins normally at the amino-terminal end and ends at the position of the altered codon. (Contrast with frame-shift mutation, missense mutation, synonymous mutation.)
Mutation in coding DNA that prevents the protein from being synthesized.
a change in one DNA base pair
a change in the genetic sequence which changes a codon from an amino acid to a stop codon
a mutation that replaces a codon for an amino acid with one of the three stop codons
A type of gene mutation that introduces an inappropriate ‘stopâ€(tm) signal into the DNA sequence, resulting in a shortened protein.
NON-sents mu-TAY-shun A point mutation that alters a codon that encodes an amino acid to one that encodes a stop codon. 341
a single DNA base pair change which results in a premature stop codon; a truncated protein may be produced
A substitution of one of the bases of DNA that results in a stop codon.
Any mutation (substitiution, addition or deletion) that changes an amino acid specifying codon into a chain terminating codon.
A single DNA base substitution resulting in a stop codon.
A single base pair substitution that prematurely codes for a stop in amino acid translation (stop codon)
Substitution of a single DNA base that results in a stop codon, thus leading to the truncation of a protein.
Base pair change in DNA that changes a codon into a chain-terminating codon.
A type of mutation that changes an amino acid codon to one of the three stop codons, resulting in a shorter and usually nonfunctional protein.
A mutation that changes a sense codon into one which does not code for an amino acid.
is any change in DNA that causes a (termination) codon to replace a codon representing an amino acid.
Any change in DNA that results in a three-base-pair sequence that does not code for an amino acid and thus terminates the protein sequence.
A mutation that changes a triplet coding for an amino acid into a termination codon.
A truncated mutation....the protein is truncated by mutation, and so dysfunctional or non-existent depending on where the mutation occurs.
mutation that alters a gene so as to produce a .
In genetics, a nonsense mutation is a point mutation in a sequence of DNA that results in a premature stop codon, or a nonsense codon in the transcribed m RNA, and possibly a truncated, and often nonfunctional protein product.