Two separate additions or deletions of one or two base pairs (reading frame shift) in a DNA sequence such that the second shift restores the reading frame, effectively ''skipping" the amino acids coded between the two.
( ORF) A DNA sequence that is potentially translatable into a protein.
An open reading frame (ORF) is a portion of a gene's sequence that contains a sequence of bases, uninterrupted by stop sequences, that could potentially encode a protein. When a new gene is identified and its DNA sequence deciphered, it is still unclear what its corresponding protein sequence is. This is because, in the absence of any other knowledge, the DNA sequence can be translated or read in six possible reading frames (three for each strand, corresponding to three different start positions for the first codon). ORF identification involves scanning each of the six reading frames and determining which one(s) contains a stretch of DNA sequence bounded by a start and stop codon, yet containing no start or stop codons within it; a sequence meeting these conditions could correspond to the actual single product of the gene. The identification of an ORF provides the first evidence that a new sequence of DNA is part or all of a gene encoding for a particular protein.
A stretch of DNA which potentially codes for protein. A length of DNA not interrupted by stop codons. A sequence of in frame codons preceded by a translational initiation codon and terminated by a chain termination triplet.
The length of DNA sequence between the translation start signal and the termination codon that can be translated into a protein; the phase in which nucleotides can be read in sets of three that results in a protein.
A series of DNA triplets that codes for amino acids without any stop signals and is potentially translatable into protein.
a DNA sequence commencing at a known point which in reading frame (every three nucleotides) does not contain any internal termination codons
a region of genomic sequence with no stop codon in frame
a sequence of DNA consisting of triplets that can be translated into amino acids starting with an initiation codon and ending with a termination codon
a stretch of DNA that have all the appropriate signals for DNA transcription and translation into a protein
Corresponds to a region of nucleotide sequence that may potentially be translated into a protein. This region usually begins with a "start" codon (nucleotide sequence 'ATG') and terminates with one of 3 "stop" codons. An ORF is not usually considered equivalent to a gene or locus until there has been shown to be a phenotype associated with a mutation in the ORF, and/ or an mRNA transcript or a gene product generated from the ORFs DNA has been detected.
(synonym: ORF) All exons of a gene that contribute to the protein product(s) of the gene
A DNA sequence with the potential to encode a protein.
That segment of a nucleic acid sequence that lies between two stop codons, when translated in a given reading frame. The presence of an open reading frame is necessary to encode a polypeptide sequence (or an exon thereof), but the presence of an open reading frame is not proof that a polypeptide sequence is encoded in that sequence.
A series of DNA codons including a 5¡¯ initiation codon and a termination codon, that encodes a putative or known gene.
(ORF) The sequence of DNA or RNA located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon).
a reading frame in a genetic sequence that does not contain a signal to stop protein translation (see below) before creating a complete protein.
a DNA sequence which is believed, on the basis of statistical evidence, to code for protein, but for which no matching protein or mRNA is known. ORFs can often be confirmed by matching their sequences to a database of known genes or EST's.
an DNA sequence that is bounded by start and stop codons; it may represent the coding sequence for a polypeptide.
Regions in a nucleotide sequence that are bounded by start and stop codons and are therefore possible gene coding regions.
(ORF) A series of codons starting with an initiation codon and ending with a termination codon; the part of a protein-coding gene that is translated into protein.
a stretch of triplet codons with an initiator codon at one end and a stop codon sat the other, as identifiable by nucleotide sequences. [Source: Agricultural Genome Information System, USDA
A stretch of DNA that when translated into an amino acid sequence doesnt contain an internal stop codon. An ORF can be evidence that a DNA sequence is part of a gene.
contains a series of triplets coding for amino acids without any termination codons; sequence is (potentially) translatable into protein.
or ORF. The is the part of the gene that is used to start the production of some RNA from a gene made of DNA.
A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain. primary transcript RNA transcript immediately after transcription in the nucleus, before RNA splicing or polyadenylation to form the mature mRNA.
An open reading frame or ORF is a portion of an organism's genome which contains a sequence of bases that could potentially encode a protein. In a gene, ORFs are located between the start-code sequence (initiation codon) and the stop-code sequence (termination codon). ORFs are usually encountered when sifting through pieces of DNA while trying to locate a gene.
