Class of enzymes that control the number and topology of supercoils in DNA. Type I enzymes cut one DNA strand, rotate it about the other, and reseal the ends. Type II enzymes cut and reseal both DNA strands.
Enzyme that makes reversible cuts in a double helical DNA molecule for the purpose of removing knots or unwinding excessive twists.
An enzyme that can mediate transitions in the structures of DNA and chromatin by its ability to break and rejoin single or double strands of DNA.
enzyme that catalyzes the reduction of supercoiling of DNA. Important during DNA replication to relieve the negative supercoiling that occurs when the two strands of the DNA double helix are separated.
An enzyme which introduces or removes overwinding or underwinding of the DNA circular duplex by causing a nick, rotating the strands, and then ligating them.
An enzyme essential to the cell replication process.
an enzyme that regulate the supercoiling structure of the DNA.
An enzymatic activity responsible for relieving excessive supercoiling in DNA.
an enzymes that change the supercoiling of DNA helices by either allowing the superhelical torsion to relax (reducing the supercoiling) or adding more twists and increasing the supercoiling.
an enzyme that can unwind the supercoiling of a DNA helix
An enzyme that can cut and re-form polynucleotide backbones in DNA to allow it to assume a more relaxed configuration.
Topoisomerase (type I: , type II: ) is an isomerase enzyme that acts on the topology of DNA and was discovered by Harvard Professor James C.
