Toxicity to nerve cells and processes resulting from too much activity.
An abnormal stimulation or activation of neurons in the brain and spinal cord that result in cell death. This stimulation is attributed to excess amounts of the neurotransmitter, glutamate.
A cascading cycle of neuronal injury and death in the central nervous system. Injured neurons release excessive amounts of glutamate which cause toxic levels of calcium flow into neighboring cells through NMDA receptor calcium channels. These cells swell and rupture, releasing more glutamate into the cellular environment (see "neuron" and "glutamate").